UTSA vs. South Florida odds, line: 2025 college football picks for Week 11 predictions from proven model - SportsLine.com

UTSA vs. South Florida Odds and Predictions for Week 11

The South Florida Bulls aim to remain contenders in the American Athletic Conference championship race as they face the UTSA Roadrunners in a crucial Thursday night game.

Team Form and Standings

Recent Performances

Game Insights and Betting Odds

The over has been common in recent games for both teams: three consecutive games for UTSA and five out of the last six for USF.

Kickoff is set for 7:30 p.m. at Raymond James Stadium in Tampa, Florida.

In their only previous meeting in 2023, UTSA defeated South Florida 49-21.

The SportsLine Projection Model "simulates every FBS game 10,000 times" to provide college football picks and betting advice.

Author’s Summary

This matchup is pivotal for conference standings, with South Florida favored at home and previous games indicating high scoring trends.

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SportsLine SportsLine — 2025-11-06