NFL Picks and Predictions for Week 6
The NFL season continues with a highly anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on October 12, 2025, at 8:30 AM EDT. The article explores some plus-money NFL picks, following a successful Week 5 where bold predictions went 2-1, resulting in a +1.17 unit gain overall, and a total gain of 2.16 units since Week 3.
Week 6 Predictions
One potential strategy is fading the Colts offense, despite their impressive performance. Indianapolis is currently averaging 3.39 points per drive, which would be the highest this century if maintained throughout the season.
Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.
Author's summary: NFL Week 6 plus-money bets analysis.
- Last week's NFL bold predictions: 2-1
- Overall gain since Week 3: +2.16 units
- Colts' current average points per drive: 3.39
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