Think Melatonin Is Safe? New Research Reveals a Hidden Heart Risk
Long-term use of melatonin for sleep issues may carry unforeseen heart risks. Recent research indicates that chronic melatonin users were nearly twice as likely to die and 3.5 times more likely to be hospitalized due to heart failure.
Melatonin Linked to Increased Risk of Heart Failure
Adults with chronic insomnia who took melatonin for a year or more showed a higher chance of developing heart failure, needing hospitalization for it, and dying from any cause compared to non-users. This preliminary study was presented at the American Heart Association's (AHA) Scientific Sessions 2025.
The study’s findings will be explored further at the AHA's annual conference, held from November 7-10 in New Orleans, which is a major event for advances in cardiovascular science and clinical research.
What Is Melatonin?
Melatonin is a hormone produced by the pineal gland that controls the body’s sleep-wake cycle, increasing at night and decreasing during the day. Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag.
- Melatonin supplements are widely available over the counter in many countries, including the U.S.
- In the U.S., melatonin products are unregulated, causing variability in purity and dosage.
"Chronic melatonin users were almost twice as likely to die and 3.5 times more likely to be hospitalized for heart failure."
Experts, who once viewed melatonin as harmless, now advise caution with long-term use due to these new findings.
Summary
Extended melatonin use may increase risks of heart failure and mortality, urging careful consideration of its long-term use despite its common reputation as a safe sleep aid.
Author’s note: While melatonin aids sleep, new evidence suggests prolonged use might pose serious heart risks, highlighting the need for cautious, informed consumption.